1、4- phenyl -1- butanol is an important pharmaceutical intermediate. Benzene and Succinic anhydride as starting material by the Friedel-Crafts acylation to get 3- carbonyl benzene acid; through to the carbonyl reduction of methyl method, identified by Wollf-Kishner reduction method for the synthesis of phenyl butyric acid, then through esterification and ester reduction with sodium borohydride and reaction synthesis of 4- phenyl -1- butanol . This synthesis method avoid the toxic zinc amalgam, eliminates the expensive lithium aluminium hydride, which is more suitable for industrial production.
2、4- phenyl -1- butanol is an important intermediate of producing saudi metro, caffeic acid phenethyl alcohol ester . |
